TRICLOSAN PROMOTES Staphylococcus aureus NASAL COLONIZATION

Author (s) : D.Jeevithra, Dr.S.Anbumalar, S.Kalaivani

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Abstract :
The biocide triclosan is used in many personal care products, including toothpastes, soaps, clothing, and medical equipment. Consequently, it is present as a contaminant in the environment and has been detected in some human fluids, including serum, urine, and milk. Staphylococcus aureus is an opportunistic pathogen that colonizes the noses and throats of approximately 30% of the population. Colonization with S. aureus is known to be a risk factor for several types of infection. Here we demonstrate that triclosan is commonly found in the nasal secretions of healthy adults and the presence of triclosan trends positively with nasal colonization by S.aureus. We demonstrate that triclosan can promote the binding of S.aureus to host proteins such as collagen, fibronectin, and keratin, as well as inanimate surfaces such as plastic and glass. Lastly, triclosan-exposed rats are more susceptible to nasal colonization with S.aureus. These data reveal a novel factor that influences the ability of S.aureus to bind surfaces and alters S.aureus nasal colonization.

Keywords : Triclosan, human fluids, nasal secretions, S.aureus

Conference Date : 13/11/2020

Pages : 55

Paper ID : 20055