SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF NOVEL MANNICH BASES DERIVED FROM ΒETA-NAPHTHOL

Author (s) : S.Brillians Revin, D.Saravanan , P.Rajeshwari & M.Malliga

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Abstract :
This present study is concerned with the synthesis of novel β-naphthol Mannich bases with benzimidazole and p-toluidine by condensation reaction with appropriate aldehydes. The compounds 3-(phenyl(p-tolylamino)methyl) naphthalene-2-ol (TNPTB)  and 3-((1H-benzo[d]imidazole-1-yl)methyl)naphthalene-2-ol (TNBIF) were synthesized and the chemical structures were characterized using spectral and analytical techniques. Mannich bases were screened for their antibacterial and antifungal activity against opportunistic bacterial and yeast pathogens. The antioxidant activity was tested using established methods. Among the tested ligands, TNBIF showed better antimicrobial and antioxidant activity compared to TNPTB.

Keywords : Mannich base, β-naphthol, p-toluidine, Benzimidazole, Antimicrobial activity,Antioxidant activity.

Conference Date : 30/08/2019

Pages : 303

Paper ID : 19294