NEW FAMILY PART OF ATAXIA TELANGIECTASIA MUTATED (ATM) KINASE

Author (s) : Dr. S. RAMARAJAN , Dr. P. POORNIMA, Ms. S. SHENBAGAVALLI

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Abstract :
KIBRA, originally identified as a protein expressed predominantly in KIDney and BRAin, has been shown to be highly expressed in breast cancer cells and plays an important role in growth and survival of breast cancer cells. Since KIBRA is widely expressed in breast cancer cells and because cell survival functions of KIBRA might counteract DNA-damage response. Our in vitro, in vivo data and from ATM over expression and ATM null model systems provide evidence that KIBRA is a physiological substrate of Ataxia Telangiectasia Mutated Kinase (ATM) - a master regulator of DNA Damage Response (DDR) pathway. We identified the site of phosphorylation by site directed mutagenesis, and further confirmed the same with motif specific antibody. Our work introduced KIBRA in ATM kinase family

Keywords : KIBRA, Ataxia Telangiectasia Mutated Kinase (ATM)

Conference Date : 13/11/2020

Pages : 117

Paper ID : 20117