NANOCOMPOSITE CONTAINING MANGANESE-COPPER MINERALS SUBSTITUTED HYDROXYAPATITE / COLLAGEN- POLY METHYLMETHACRYLATE FOR BONE TISSUE ENGINEERING

Author (s) : Ms.S.VINOTHINI, Mrs.R.SANGEETHA

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Abstract :
Poly (methylmethacrylate) (PMMA) is one of the most prevalent causes of bone cement. The characteristics of this bone cement have prompted many scientists to attempt to improve its properties. In the present investigation, the blending process was used to fabricate biocomposite of collagen-PMMA (Col-PMMA) and manganese and copper substituted hydroxyapatite (Mn-Cu-HA) (Mn-Cu-HA/Col-PMMA). It studied physiochemical properties, biological properties and cytocompatibility. A strong incorporation of the mineral ions into the hydroxyapatite and a great distribution of the Mn-Cu-HA inside the Col-PMMA matrix phase were shown by physicochemical screening. More apatite development on the substrate after soaking in the SBF solution has been found in bioactivity tests. In vitro growth studies in the biocomposite case using osteoblast like cells demonstrated that following 7 days of soaking, the binding, feasibility and propagation of the cells on the scaffolds had increased. It can therefore be inferred that Mn-Cu-HA/Col-PMMA biocomposite bone cement with enhanced physicochemical characteristics can be a great alternative for commonly employed bone cements in cartilage regeneration.

Keywords : Nanoparticles; Biocomposite; Hydroxyapatite; Collagen; Poly (methyl methacrylate).

Conference Date : 13/11/2020

Pages : 220

Paper ID : 20220