METAL IONS CO-SUBSTITUTED HYDROXYAPATITE BASED NANOBIOCOMPOSITE IMPLANT FOR ORTHOPEDIC APPLICATIONS

Author (s) : A.DEEPA and R.SANGEETHA

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Abstract :
Biocompatible chemically-synthesized hydroxyapatite (HA) is extensively used in bone treatments, controlled drug release and dental implants. To conquer these challenges, cerium- copper minerals co- substituted hydroxyapatite (Sr-Cu-HA)/ poly (methyl methacrylate) (PMMA) (Sr-Cu-HA/ PMMA) bio-composite have been fabricated through solvent vanishing technique. The Fourier transform infrared (FTIR), X-Ray diffraction (XRD), scanning electron microscope- energy dispersive X-Ray spectroscopy (SEM- EDX) and transmission electron microscopy- Selected area diffraction (TEM- SAD) study established the existence of Sr-Cu-HA in the PMMA matrix. Moreover, the as-fabricated biocomposite demonstrated strong bactericidal activity on gram-negative bacteria (E.coli) and gram-positive bacteria (Klebsiella ) which may be owing to the action of release of Sr and Cu ions on the exterior that chunks the carrying channels of the cell leading to the cell bereavement. The biological investigations recommended that the as-fabricated bio-composite promotes the propagation, ALP action, calcium deposition and collagen formation of osteoblast cells co- colonization on the Sr-Cu-HA/PMMA bio-composite. Therefore, the as-prepared bio- composite confirm outstanding versatile properties that could be employing in bone tissue engineering.

Keywords : Nanoparticles; Bio-composite; Biocompatibility; antibacterial activity; Osteogenic; Osseointegration; PMMA

Conference Date : 30/08/2019

Pages : 39

Paper ID : 19037