EVALUATION OF ANTIMICROBIAL POTENTIAL OF FRUIT PEEL AND PLANT SEEDS AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCUS AUREUS

Author (s) : DR.A.SUMITHRA

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Abstract :
Multidrug-resistant Staphylococcus aureus (MDR-SA) poses a significant threat to public health, leading to increased morbidity and mortality worldwide. As conventional antibiotics continue to lose efficacy against this formidable pathogen, alternative strategies are urgently needed. This study aimed to investigate the antimicrobial potential of fruit peel and plant seeds extracts against MDR-SA strains. The experiment involved the collection and extraction of bioactive compounds from the peels of select fruits and seeds of specific plant species. The fruit peel extracts were derived from citrus fruits (e.g., oranges, lemons) and plant seeds were sourced from seeds (e.g., grape seeds, avocado seeds). The extraction process involved various solvents to obtain a range of compounds with potential antimicrobial properties. To evaluate the antimicrobial activity, a panel of clinically isolated MDR-SA strains, obtained from hospital samples, were used. Results revealed that certain fruit peel and plant seed extracts exhibited notable antimicrobial activity against MDR-SA strains. The inhibition zones observed in the disk diffusion tests demonstrated varying degrees of growth inhibition, indicating potential efficacy. Moreover, the broth microdilution assay confirmed the inhibitory effect of the extracts by determining the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs). In conclusion, this study highlights the promising antimicrobial potential of fruit peel and plant seed extracts against multidrug-resistant Staphylococcus aureus. The identification of active compounds may pave the way for the development of novel antimicrobial agents or adjuvants to combat MDR-SA infections. However, further research is warranted to elucidate the underlying mechanisms of action and assess the safety and efficacy of these natural extracts in vivo. Embracing alternative sources of antimicrobial agents could hold promise for tackling the growing threat of antibiotic resistance.

Keywords : Multidrug-resistant, Staphylococcus aureus, Bioactive

Conference Date : 13/11/2020

Pages : 261

Paper ID : 20261