BEGINNING WITH DIETHYL GALACTARATE, 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES ARE SYNTHESIZED

Author (s) : T.Sudha, K.Kokila, R.Senbahavalli, Dr.S.Prillians revin

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Abstract :
The synthesis of a number of bis (1,4-disubstituted-1,2,3-triazoles) is described in this communication, starting from the well-known (2,3,4,5) bis acetonide-protected diethyl galactarate (1). When 1 was reduced with LiAlH4, the result was dioxolane 2, which was then treated with CBr4 to produce the matching dibromide 3 (80%). The crucial diazide 4 (95% yield) was produced when 3 and NaN3 were combined in DMF. The bis (1,4-disubstituted-1,2,3 triazoles) 5-8 were produced from the diazide 4 through click reactions with alkyl-substituted acetylenes, such as triphenyltinacetylene. The novel compounds' physical properties are reported, along with a few 1H, 13C, and 119Sn NMR data values.

Keywords : Bis (1, 4-disubstituted-1, 2, 3-triazoles); triphenyltin substituents; galactaric framework; physical properties

Conference Date : 13/11/2020

Pages : 26

Paper ID : 20026