ANTICANCER POTENTIAL OF SUGAR-APPLE (SITAPHAL) ANNONA SQUAMOSA EXTRACT AGAINST HUMAN BREAST CANCER (MCF-7) CELL LINE

Author (s) : Jayanthi.C, Vijaya.C

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Abstract :
The most common type of breast cancer is known as Hormone Receptor-Positive breast cancer; accounting for around 75% of all breast cancers. Breast cancer is characterized by the un controlled growth of abnormal cells in the milk producing glands of the breast or in the passages (ducts) that deliver milk to the nipples. Extraction of fruit extracts of fruit with Methanol, Chloroform, Ethyl acetate, Hexane and Aqueous revealed that methanol gave yield of extract. Various parts of Annona squamosa (leaves, seeds and barks) have been investigated for antibacterial actions against common pathogens commonly encountered in clinical practice. In the present study the crude extracts of custard apple endocarp when standardized by MTT assay for fruit extracts at varying concentrations for 24h against MCF-7 cells, a change in per cent cell viability of cells were observed. The control cells were 100% viable. Moreover, identification of active methanolic extract of Annona Squamoma fruit as showed promising anticancer properties against human breast cancer (MCF-7) cell line has successfully isolated and identified active constituents responsible for therapeutic potential.

Keywords : Annona Squamoma fruit, Methanol, Chloroform, Ethyl acetate, Hexane and Aqueous, DMEM, TSM, IC50, MTT assay.

Conference Date : 13/11/2020

Pages : 69

Paper ID : 20069