ABUTILON INDICUM EXTRACTS: ANTIBACTERIAL & ANTIOXIDANT

Author (s) : S.CHANDRALEKHA & K.HAMSA

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Abstract :
Abutilon indicum LINN, commonly known as Indian mallow or country mallow, is a medicinal plant with a long history of traditional use in various cultures. In this study, we investigated the antibacterial and antioxidant properties of different extracts obtained from Abutilon indicum LINN leaves.The leaves of Abutilon indicum were subjected to sequential extraction using solvents of varying polarities, including petroleum ether, chloroform, ethyl acetate, and methanol. The resulting extracts were evaluated for their antibacterial activity against a panel of clinically relevant bacterial strains using the disc diffusion and broth microdilution methods. Additionally, the antioxidant potential of the extracts was assessed using various in vitro assays, such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing antioxidant power (FRAP), and total phenolic content determination.The results revealed significant antibacterial activity of the methanol and ethyl acetate extracts against Gram-positive and Gram-negative bacterial strains. These extracts exhibited pronounced inhibitory effects, suggesting the presence of potent antibacterial compounds in Abutilon indicum leaves. The petroleum ether and chloroform extracts showed moderate antibacterial activity, mainly against Gram-positive bacteria. Furthermore, the methanol extract exhibited the highest antioxidant activity among all the extracts tested, as evidenced by its strong DPPH radical scavenging capacity and high FRAP value. The methanol extract also exhibited the highest total phenolic content, indicating a correlation between phenolic compounds and antioxidant potential in Abutilon indicum leaves.Overall, the findings from this study highlight the therapeutic potential of Abutilon indicum LINN leaves as a source of natural antibacterial and antioxidant agents. These results may contribute to the development of novel pharmaceuticals or nutraceuticals to combat bacterial infections and oxidative stress-related disorders. However, further studies are warranted to isolate and identify the bioactive compounds responsible for the observed activities and to explore their mechanisms of action in greater detail.

Keywords : Abutilon indicum, phenolic content determination, nutraceuticals.

Conference Date : 30/08/2019

Pages : 181

Paper ID : 19175