NANOTOPOGRAPHICAL CONTROL OF STEM CELL DIFFERENTIATION

Author (s) : J.Seethalakshmi, T.Bhuvana

---

Abstract :
The ability to accurately direct stem cell fate determination would have enormous possibilities for basic research and clinical therapy because stem cells can differentiate into a variety of lineages. Given that the features are more robust than surface chemistry and can be altered in size and shape to fit the intended application, nanotopography offers a handy tool for guiding differentiation. The use of nanotopography to direct differentiation is discussed in the context of several subsets of stem cells in this work, with a special emphasis on skeletal (mesenchymal) stem cells. examine the potential effects of direct (force-mediated) and indirect (biochemical signal-mediated) mechanotransduction in addressing the molecular foundation underlying the topographical effects on stem cells. In order to understand how topography affects fate determination, data from proteomic research is also discussed. This method sheds light on the broad molecular alterations at the level of the functional effectors.

Keywords : stem cell, nanotopography.

Conference Date : 13/11/2020

Pages : 286

Paper ID : 20286