SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL PROPERTIES OF MANNICH BASE CYCLIZATION DERIVATIVES OF BENZIMIDAZOLE AND THEIR METAL COMPLEXES

Author (s) : R.Kavitha, P.S.Sujaponmini, R.Menaga & M.Kokila

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Abstract :
Novel Mannich base cyclization derivatives of Benzimidazole were prepared through three-component condensation reaction of 2-aminobenzimidazole with formaldehyde and primary amines. All the compounds were characterized through spectral and analytical data. The transition metal complexes of resultant Mannich bases have been synthesized and well characterized by elemental analyses, spectral studies, magnetic moment determination, molar conductivity measurement and Thermogravimetric analysis. Experimental results showed that metal complexes act as bi-dentate ligands. The in-vitro antibacterial and antifungal activity of Mannich bases and their metal (II) complexes was assayed against different pathogens using MIC method. All the compounds and their metal complexes showed good potency against various microorganisms. The synthesized compounds and their metal complexes were also screened for their cytotoxicity and results showed that only Ni (II) complexes exhibit cytotoxicity while all other compounds were almost inactive.

Keywords : Mannich bases, Benzimidazole, Metal complexes, Anti-microbial agents

Conference Date : 17/09/2021

Pages : 199

Paper ID : IESMDT197