THE CREATION, CHARACTERIZATION, AND BIOLOGICAL ACTIVITY OF COPPER (II) COMPLEXES AND HYDRAZONES

Author (s) : K.Kokila, Dr.Sivaprumal, Dr.R.Senbahavalli, Dr.R.Kavitha

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Abstract :
There are many different biological activity pathways for copper due to the metal's fundamental role as a redox-active component of various metabolic enzymes. Potent antiproliferative, antibacterial, nuclease, anti-inflammatory, and antimycobacterial actions are known to be displayed by copper (II) coordination compounds. Hydrazones are chemical ligands with antibacterial, antiviral, and antifungal characteristics that are frequently utilized for complexation with copper (II). The improved pharmacological activity of the system may be caused by copper-ligand interaction, which may promote charge delocalization and increase net hydrophobicity of the system. Hydrazone, nitrofurantoin, and ftivazide are coordination compounds of Cu(II) with 4,6-di-tert-butyl-2,3-dihydroxybenzaldehyde that have been synthesized, characterized using elemental and XRD analysis, FT-IR, UV-Vis, and NMR spectroscopy, and tested for antibacterial activity on Gram-positive and Gram-negative bacteria in vitro.

Keywords : Hydrazones; copper (II) complexes; antibacterial activity

Conference Date : 17/09/2021

Pages : 141

Paper ID : IESMDT139