HYALURONIC ACID/ALBUMIN COATED CARBOXYMETHYL CELLULOSE-ALBUMIN NANOPARTICLES AS A TARGETABLE DRUG DELIVERY SYSTEM FOR SKIN CANCER

Author (s) : Dr.M.USHARANI

---

Abstract :
Conventional  cancer  chemotherapies  cannot  distinguish  between  normal  and  cancer  cells,  and  lead  to severe  systemic  toxicity and side  effects. In  the  past  decades,  different  kinds  of  drug  delivery  systems have  been  developed  to  overcome  these  limitations. In this study, carboxymethyl cellulose (ALG) and egg albumin (EA) nanoparticles (NPs) loaded with curcumin (CUR) were synthesized by self assembly method and fabricated with hyaluronic acid (FA) and albumin by layer by layer technique. The synthesized nanoparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and morphology was observed under field emission scanning electron microscope (FE-SEM). Particle size, poly-dispersity index and zeta potential were also evaluated. Curcumin could be loaded into the nanoparticles due to electrostatic and intermolecular interaction with high entrapment efficiency of 93% and loading capacity of 11.1%.  The release test showed that 2-HA/EA/CMC-EA-CUR exhibited sustained drug release at acidic pH in tumor environment. The analysis of MEL-39 cells cytotoxicity suggested that curcumin-loaded NPs exhibited higher toxicity compared to free curcumin. The obtained hyaluronic acid/albumin coated carboxymethyl cellulose-egg albumin nanoparticlesloaded with curcumin might be a potential candidate for targeted skin cancer drug delivery.

Keywords : curucmin, hyaluronic acid, carboxymethyl cellulose, egg albumin, skin cancer, targeted drug delivery.

Conference Date : 17/09/2021

Pages : 127

Paper ID : IESMDT125